PARK7 Recombinant Mouse Monoclonal Antibody [PSH23-77] (HA601612)

UNIPROT #

Q99497

PROTEIN NAME

PARK7

SYNONYMS

CAP1 antibody;DJ-1 antibody;DJ1 antibody;DJ1 protein antibody;Epididymis secretory sperm binding protein Li 67p antibody;FLJ27376 antibody;FLJ34360 antibody;FLJ92274 antibody;HEL S 67p antibody;Oncogene DJ1 antibody;OTTHUMP00000001348 antibody;OTTHUMP00000001349 antibody;OTTHUMP00000001350 antibody;OTTHUMP00000001351 antibody;PARK7 antibody;PARK7_HUMAN antibody;Parkinson disease (autosomal recessive, early onset) 7 antibody;Parkinson disease protein 7 antibody;Parkinson protein 7 antibody;Protein DJ-1 antibody;SP22 antibody

SUBCELLULAR LOCATION

Cell membrane, Cytoplasm, Nucleus, Membrane raft, Mitochondrion, Endoplasmic reticulum.

FUNCTION

The gene PARK7, also known as DJ-1, encodes a protein of the peptidase C56 family. The human gene PARK7 has 8 exons and locates at chromosome band 1p36.23. DJ-1 was shown to prevent metabolite and protein damage caused by a glycolytic metabolite. This metabolite has been suggested and confirmed to be cyclic 3-phosphoglycerate (or cyclic 3-phosphoglyceric anhydride). Catalytic efficiency of DJ-1 as a hydrolase of cyclic 3-phosphoglyceric anhydride is 10,000 times higher than other reported enzymatic activities of DJ-1. Under an oxidative condition, DJ-1 inhibits the aggregation of α-synuclein via its chaperone activity, thus functioning as a redox-sensitive chaperone and as a sensor for oxidative stress. Accordingly, DJ-1 apparently protects neurons against oxidative stress and cell death. In parallel, protein DJ-1 acts as a positive regulator of androgen receptor-dependent transcription. DJ-1 is expressed in both the neural retina and retinal pigment epithelium of mammals, where it exerts a neuroprotective role against oxidative stress under both physiological and pathological conditions.