Pan-Cadherin Recombinant Antibody - Rat IgG1 (Chimeric) (IRS287RT)

UNIPROT #

P12830

PROTEIN NAME

Pan-Cadherin

SYNONYMS

Cadherin antibody;CDH3 antibody;CDHP antibody;7B4 antigen antibody;Cadherin-1 antibody;Cadherin-2 antibody;Cadherin-3 antibody;Cadherin-4 antibody;Cadherin-5 antibody;CAM 120/80 antibody;CD144 antibody;CD324 antibody;CD325 antibody;Cdh4 antibody;CDH5 antibody;CDHE antibody;CDHN antibody;E-cadherin antibody;Epithelial cadherin antibody;N-cadherin antibody;NCAD antibody;Neural cadherin antibody;P-cadherin antibody;Placental cadherin antibody;UVO antibody;Uvomorulin antibody;Vascular endothelial cadherin antibody

SUBCELLULAR LOCATION

Cell membrane, Cell junction, Endosome, Golgi apparatus.

FUNCTION

Cadherins comprise a family of Ca2+-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. The classical cadherins, E-, N- and P-cadherin, consist of large extracellular domains characterized by a series of five homologous NH₂ terminal repeats. The most distal of these cadherins is thought to be responsible for binding specificity, transmembrane domains and carboxy terminal intracellular domains. The relatively short intracellular domains interact with a variety of cytoplasmic proteins, such as -catenin, to regulate cadherin function. Members of this family of adhesion proteins include rat cadherin K (and its human homolog, cadherin, R-cadherin, B-cadherin, E/P cadherin and cadherin-5.