p47-phox Recombinant Mouse Monoclonal Antibody [A6B10-R] (HA601264)

UNIPROT #

P14598

PROTEIN NAME

p47-phox

SYNONYMS

47 kDa autosomal chronic granulomatous disease protein antibody;47 kDa neutrophil oxidase factor antibody;NADPH oxidase organizer 2 antibody;NCF 47K antibody;NCF-1 antibody;NCF-47K antibody;Ncf1 antibody;NCF1_HUMAN antibody;Neutrophil cytosol factor 1 antibody;Neutrophil cytosolic factor 1 antibody;neutrophil cytosolic factor 1, (chronic granulomatous disease, autosomal 1) antibody;Neutrophil NADPH oxidase factor 1 antibody;Nox organizer 2 antibody;Nox organizing protein 2 antibody;Nox-organizing protein 2 antibody;NOXO2 antibody;p47 phox antibody;p47-phox antibody;SH3 and PX domain containing protein 1A antibody;SH3 and PX domain-containing protein 1A antibody;SH3PXD1A antibody

SUBCELLULAR LOCATION

Cytoplasm, cytosol, Membrane.

FUNCTION

The heredity chronic granulomatous disease (CGF) has been linked to mutations in p47phox and p67-phox. The cytosolic proteins p47phox and p67-phox, also designated neutrophil cytosol factor (NCF)1 and NCF2, respectively, are required for activation of the superoxide-producing NADPH oxidase in neutrophils and other phagocytic cells. During activation of the NADPH oxidase, p47phox and p67-phox migrate to the plasma membrane where they associate with cytochrome b558 and the small G protein Rac to form the functional enzyme complex. Both p47phox and p67-phox contain two Src homology 3 (SH3) domains. The C-terminal SH3 domain of p67-phox has been shown to interact with the proline-rich domain of p47phox, suggesting that p47phox may faciliate the transport of p67-phox to the membrane.