Olig2 Recombinant Rabbit Monoclonal Antibody (IRS067)

UNIPROT #

Q9EQW6

PROTEIN NAME

Olig2

SYNONYMS

Basic domain helix loop helix protein class B 1 antibody;Basic helix loop helix protein class B 1 antibody;BHLHB antibody;bHLHB1 antibody;bHLHe19 antibody;Class B basic helix loop helix protein 1 antibody;Class B basic helix-loop-helix protein 1 antibody;class E basic helix loop helix protein 19 antibody;Class E basic helix-loop-helix protein 19 antibody;Human protein kinase C binding protein RACK17 antibody;Olig2 antibody;OLIG2_HUMAN antibody;Oligo2 antibody;Oligodendrocyte lineage transcription factor 2 antibody;Oligodendrocyte specific bHLH transcription factor 2 antibody;Oligodendrocyte transcription factor 2 antibody;OTTHUMP00000067569 antibody;OTTHUMP00000067570 antibody;PRKCBP2 antibody;Protein kinase C binding protein 2 antibody;Protein kinase C binding protein RACK17 antibody;Protein kinase C-binding protein 2 antibody;Protein kinase C-binding protein RACK17 antibody;RACK17 antibody

TISSUE SPECIFICITY

Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable.

SUBCELLULAR LOCATION

Nucleus, Cytoplasm.

FUNCTION

The oligodendrocyte lineage-specific basic helix-loop-helix (OLIG) family of transcription factors include OLIG1-OLIG3, which differ in tissue expression. OLIG1 and OLIG2 are specifically expressed in nervous tissue as gene regulators of oligodendrogenesis. OLIG2 is more widely expressed in embryonic brain than OLIG1, while OLIG3 is primarily expressed in non-neural tissues. OLIG1 and OLIG2 interact with the Nkx-2.2 homeodomain protein, which is responsible for directing ventral neuronal patterning in response to graded Sonic hedgehog signaling in the embryonic neural tube. These interactions between OLIG proteins and Nkx-2.2 appear to promote the formation of alternate cell types by inhibiting V3 interneuron development. OLIG1 and OLIG2 are abundantly expressed in oligodendroglioma and nearly absent in astrocytomas. Therefore, OLIG proteins are candidates for molecular markers of human glial brain tumors, which are the most common primary malignancies of the human brain.