NK1.1 Recombinant Rabbit Monoclonal Antibody [PSH22-99] (HA724338)

UNIPROT #

P27814

PROTEIN NAME

NK1.1

SYNONYMS

CD161 antigen like family member C antibody;CD161 antigen-like family member C antibody;CD161c antibody;Killer cell lectin-like receptor subfamily B member 1C antibody;Klrb1c antibody;Klrb1f antibody;KLRBC_MOUSE antibody;Ly-55c antibody;Ly55c antibody;Lymphocyte antigen 55c antibody;Lymphocyte antigen 59 antibody;Natural killer cell surface protein P1-40 antibody;NK1.1 antibody;NKR P1.9 antibody;NKR P1C antibody;NKR-P1 40 antibody;NKR-P1.9 antibody;NKR-P1C antibody;NKRP1 antibody

SUBCELLULAR LOCATION

Membrane.

FUNCTION

Killer cell lectin-like receptor subfamily B, member 1, also known as KLRB1, NKR-P1A or CD161 (cluster of differentiation 161), is a human gene. Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein, NKR-P1A or CD161, is classified as a type II membrane protein because it has an external C terminus. NKR-P1A, the receptor encoded by the KLRB1 gene, recognizes Lectin Like Transcript-1 (LLT1) as a functional ligand. Its engagement by NKR-P1 leads to clustering of the latter on the NK cell surface mediating an inhibitory signalling.