Neurogranin Recombinant Rabbit Monoclonal Antibody - BSA and Azide free [PSH02-96] (HA750851)

UNIPROT #

Q92686

PROTEIN NAME

Neurogranin

SYNONYMS

Protein kinase C substrate RC3 antibody;Calmodulin binding protein antibody;Hng antibody;NEUG(55-78) antibody;NEUG_HUMAN antibody;Neurogranin (protein kinase C substrate) antibody;Ng antibody;NRGN antibody;Protein kinase C substrate antibody;RC3 antibody

SUBCELLULAR LOCATION

Axon, cytosol, dendritic spine head, glutamatergic synapse, mitochondrial membrane, neuronal cell body, postsynaptic membrane, trans-Golgi network transport vesicle membrane.

FUNCTION

Neurogranin is a calmodulin-binding protein expressed primarily in the brain, particularly in dendritic spines, and participating in the protein kinase C signaling pathway. Neurogranin has recently been found in aortic endothelial cells and cardiomyocytes. Neurogranin is the main postsynaptic protein regulating the availability of calmodulin, binding to it in the absence of calcium. Phosphorylation by protein kinase C lowers its binding ability. NRGN gene expression is controlled by thyroid hormones. Human neurogranin consists of 78 amino acids. One study tells of potential link of neurogranin gene to the heightened risk of schizophrenia in males, another study gives evidence of lowered neurogranin immunoreactivity in the brains of people suffering from schizophrenia. Neurogranin concentration in cerebrospinal fluid (CSF) is further discussed as marker for synaptic dysfunction in age-related neurodegeneration. It has also been shown to be specifically increased in patients with Alzheimer's disease. Especially, the ratio of CSF neurogranin trunc P75 and the beta-secretase BACE1 is suggested as a potential marker for cognitive deterioration in the progress of Alzheimer's disease.