Nav1.6 / SCN8A Recombinant Rabbit Monoclonal Antibody - BSA and Azide free [PSH22-36] (HA751861)

UNIPROT #

Q9UQD0

PROTEIN NAME

Nav1.6 / SCN8A

SYNONYMS

CerIII antibody;CIAT antibody;EIEE13 antibody;hNa6/Scn8a voltage gated sodium channel antibody;MED antibody;Motor endplate disease antibody;NaCh 6 antibody;NaCh6 antibody;Nav 1.6 antibody;Nbna1 antibody;peripheral nerve protein type 4 antibody;PN 4 antibody;PN4 antibody;SCN8A antibody;SCN8A_HUMAN antibody;Sodium channel protein type 8 alpha subunit antibody;Sodium channel protein type 8 subunit alpha antibody;Sodium channel protein type VIII alpha subunit antibody;Sodium channel protein type VIII subunit alpha antibody;Sodium channel voltage gated type VIII alpha antibody;Sodium channel voltage gated type VIII alpha polypeptide antibody;Sodium channel voltage gated type VIII alpha subunit antibody;Voltage gated sodium channel subunit alpha Nav1.6 antibody;Voltage-gated sodium channel subunit alpha Nav1.6 antibody

SUBCELLULAR LOCATION

Cell membrane, Cell projection, axon; Cytoplasmic vesicle, Cell projection, podosome.

FUNCTION

Sodium channel protein type 8 subunit alpha also known as Nav1.6 is a membrane protein encoded by the SCN8A gene. Nav1.6 is one sodium channel isoform and is the primary voltage-gated sodium channel at each node of Ranvier. The channels are highly concentrated in sensory and motor axons in the peripheral nervous system and cluster at the nodes in the central nervous system.