NAIP Recombinant Rabbit Monoclonal Antibody [JE39-24] (HA722550)

UNIPROT #

Q13075

PROTEIN NAME

NAIP

SYNONYMS

Baculoviral IAP repeat containing 1 antibody;Baculoviral IAP repeat-containing protein 1 antibody;BIRC 1 antibody;BIRC1 antibody;BIRC1_HUMAN antibody;Birc1a antibody;FLJ42520 antibody;NAIP antibody;Naip1 antibody;Neuronal apoptosis inhibitory protein antibody;NLR family apoptosis inhibitory protein antibody;NLR family BIR domain containing 1 antibody;NLRB 1 antibody;NLRB1 antibody;Nucleotide binding oligomerization domain leucine rich repeat and BIR domain containing 1 antibody;Psi neuronal apoptosis inhibitory protein antibody;psiNAIP antibody;Similar to occludin antibody

SUBCELLULAR LOCATION

Basolateral plasma membrane, canonical inflammasome complex, cytoplasm.

FUNCTION

Baculoviral IAP repeat-containing protein 1 is a protein that in humans is encoded by the NAIP gene. This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This copy of the gene is full length; additional copies with truncations and internal deletions are also present in this region of chromosome 5q13. It is thought that this gene is a modifier of spinal muscular atrophy caused by mutations in a neighboring gene, SMN1. The protein encoded by this gene contains regions of homology to two baculovirus inhibitor of apoptosis proteins, and it is able to suppress apoptosis induced by various signals. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.