Myogenin Recombinant Mouse Monoclonal Antibody [PSH22-35] (HA601587)

UNIPROT #

P15173

PROTEIN NAME

Myogenin

SYNONYMS

bHLHc3 antibody;cb553 antibody;Class C basic helix-loop-helix protein 3 antibody;MYF 4 antibody;Myf-4 antibody;MYF4 antibody;MYOG antibody;MYOG_HUMAN antibody;Myogenic factor 4 antibody;Myogenic factor 4 myogenin antibody;Myogenin antibody;Myogenin myogenin factor 4 antibody;OTTHUMP00000039094 antibody

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Myogenin, is a transcriptional activator encoded by the MYOG gene. Myogenin is a muscle-specific basic-helix-loop-helix (bHLH) transcription factor involved in the coordination of skeletal muscle development or myogenesis and repair. Myogenin is a member of the MyoD family of transcription factors, which also includes MyoD, Myf5, and MRF4. In mice, myogenin is essential for the development of functional skeletal muscle. Myogenin is required for the proper differentiation of most myogenic precursor cells during the process of myogenesis. When the DNA coding for myogenin was knocked out of the mouse genome, severe skeletal muscle defects were observed. Mice lacking both copies of myogenin (homozygous-null) suffer from perinatal lethality due to the lack of mature secondary skeletal muscle fibers throughout the body. In cell culture, myogenin can induce myogenesis in a variety of non-muscle cell types.