MyoD1 Recombinant Rabbit Monoclonal Antibody - BSA and Azide free [JM10-72] (HA750395)

UNIPROT #

P15172

PROTEIN NAME

MyoD1

SYNONYMS

bHLHc1 antibody;Class C basic helix-loop-helix protein 1 antibody;MYF 3 antibody;Myf-3 antibody;MYF3 antibody;Myoblast determination protein 1 antibody;Myod 1 antibody;MYOD antibody;MYOD1 antibody;MYOD1_HUMAN antibody;Myogenic differentiation 1 antibody;Myogenic factor 3 antibody;Myogenic factor MYF 3 antibody;Myogenin D1 antibody;PUM antibody

POST-TRANSLATIONAL MODIFICATION

Phosphorylated by CDK9. This phosphorylation promotes its function in muscle differentiation.; Acetylated by a complex containing EP300 and PCAF. The acetylation is essential to activate target genes. Conversely, its deacetylation by SIRT1 inhibits its function (By similarity).; Ubiquitinated on the N-terminus; which is required for proteasomal degradation.; Methylation at Lys-104 by EHMT2/G9a inhibits myogenic activity.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

MyoD, also known as myoblast determination protein 1, is a protein in animals that plays a major role in regulating muscle differentiation. MyoD, which was discovered in the laboratory of Harold M. Weintraub, belongs to a family of proteins known as myogenic regulatory factors (MRFs). These bHLH (basic helix loop helix) transcription factors act sequentially in myogenic differentiation. Vertebrate MRF family members include MyoD1, Myf5, myogenin, and MRF4 (Myf6). In non-vertebrate animals, a single MyoD protein is typically found. MyoD is one of the earliest markers of myogenic commitment. MyoD is expressed at extremely low and essentially undetectable levels in quiescent satellite cells, but expression of MyoD is activated in response to exercise or muscle tissue damage. The effect of MyoD on satellite cells is dose-dependent; high MyoD expression represses cell renewal, promotes terminal differentiation and can induce apoptosis. Although MyoD marks myoblast commitment, muscle development is not dramatically ablated in mouse mutants lacking the MyoD gene. This is likely due to functional redundancy from Myf5 and/or Mrf4. Nevertheless, the combination of MyoD and Myf5 is vital to the success of myogenesis.