MSK1 Recombinant Rabbit Monoclonal Antibody - BSA and Azide free [PSH13-72] (HA751485)

UNIPROT #

O75582

PROTEIN NAME

MSK1

SYNONYMS

90 kDa ribosomal protein S6 kinase 5 antibody;EC 2.7.11.1 antibody;KS6A5_HUMAN antibody;MGC1911 antibody;Mitogen and stress activated protein kinase 1 antibody;MSPK1 antibody;Nuclear Mitogen And Stress Activated Protein Kinase 1 antibody;Nuclear mitogen- and stress-activated protein kinase 1 antibody;Ribosomal protein S6 kinase 90kD polypeptide 5 antibody;Ribosomal protein S6 kinase 90kDa antibody;Ribosomal protein S6 kinase 90kDa polypeptide 5 antibody;Ribosomal Protein S6 Kinase Alpha 5 antibody;Ribosomal protein S6 kinase alpha-5 antibody;RLPK antibody;RPS6KA5 antibody;RSK Like Protein Kinase antibody;RSK-like protein kinase antibody;RSKL antibody;S6K alpha 5 antibody;S6K-alpha-5 antibody

SUBCELLULAR LOCATION

Nucleus, Cytoplasm.

FUNCTION

The family of ribosomal S6 kinases (Rsks), designated Rsk-1, Rsk-2 and Rsk-3, have been implicated as important signaling intermediates in response to a broad range of ligand-activated receptor tyrosine kinases. A unique feature common to the three members of the Rsk family is that each possesses two non-identical complete kinase catalytic domains. A related S6 kinase, p70 S6 kinase, functions to phosphorylate the S6 protein on ribosomal 40S subunits. p70 S6 kinase b shares high sequence homology with p70 S6 kinase, except in the carboxy terminus where it contains a proline-rich domain that may be involved in SH3 domain containing protein interactions. MSK1 (also designated RLPK) is related to Rsk and p70 S6 kinase family members and is thought to be structurally similar to Rsk family members, but it may be regulated by distinct mechanisms.