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Mouse Osteocalcin/BGLAP (50-95) peptide Protein (HA211500)

Price: Regular price $149.00

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Catalog# HA211500

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Product Details

Product Type

Protein

Product Name

Mouse Osteocalcin/BGLAP (50-95) peptide Protein (HA211500)

Protein construction description

YLGASVPSPDPLEPTREQCELNPACDELSDQYGLKTAYKRIYGITI

Accession

P86546

Protein construction

Osteocalcin/BGLAP (50-95)

Bio Activity

Testing in progress.

Formulation

Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.

Species

Mouse

Background

Osteocalcin, also known as bone gamma-carboxyglutamic acid-containing protein (BGLAP), is a small noncollagenous protein hormone found in bone and dentin, first identified as a calcium-binding protein. Because osteocalcin has gla domains, its synthesis is vitamin K2-dependent. Regulates of energy metabolism by acting as a hormone favoring pancreatic beta-cell proliferation, insulin secretion and sensitivity and energy expenditure. Also acts as a regulator of brain development: osteocalcin hormone crosses the blood-brain barrier and acts as a ligand for GPR158 on neurons, initiating a signaling response that prevents neuronal apoptosis in the hippocampus, favors the synthesis of all monoamine neurotransmitters and inhibits that of gamma-aminobutyric acid (GABA). Osteocalcin also crosses the placenta during pregnancy and maternal osteocalcin is required for fetal brain development.

Usage Guide

Shipping

In general, recombinant proteins are provided as lyophilized powder which are shipped with blue ice. Bulk packages of recombinant proteins are provided as frozen liquid which are shipped with dry ice.

Storage

Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃ It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.

Reconstitution

Reconstitute at 250 μg/ml in sterile water.

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