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Mouse CCL5/RANTES, C-hFc Tag Protein (HA211095)

Price: Regular price $800.00

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Catalog# HA211095

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  • Mouse

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Product Details

Product Type

Protein

Product Name

Mouse CCL5/RANTES, C-hFc Tag Protein (HA211095)

Predicted molecular mass

34.6 kD

Protein construction description

A DNA sequence encoding the mouse CCL5/RANTES protein (P30882) (Ser 24-Ser 91) was expressed with a human IgG1 Fc tag at the C-terminus.

Accession

P30882

Protein construction

CCL5/RANTES (24-91) | hFc

Source

HEK293

Purity

>95% as determined by SDS-PAGE.

Endotoxin

Less than 1.0 EU per μg by the LAL method.

Formulation

Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.

Species

Mouse

Background

Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells.

Usage Guide

Shipping

In general, recombinant proteins are provided as lyophilized powder which are shipped with blue ice. Bulk packages of recombinant proteins are provided as frozen liquid which are shipped with dry ice.

Storage

Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20C to -80C It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.

Reconstitution

Reconstitute at 250 μg/ml in sterile water.

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