MMP-9 Recombinant Rabbit Monoclonal Antibody [PSH19-80] (HA724104)

UNIPROT #

P41245

PROTEIN NAME

MMP-9

SYNONYMS

82 kDa matrix metalloproteinase-9 antibody;92 kDa gelatinase antibody;92 kDa type IV collagenase antibody;CLG 4B antibody;CLG4B antibody;Collagenase Type 4 beta antibody;Collagenase type IV 92 KD antibody;EC 3.4.24.35 antibody;Gelatinase 92 KD antibody;Gelatinase B antibody;Gelatinase beta antibody;GelatinaseB antibody;GELB antibody;Macrophage gelatinase antibody;MANDP2 antibody;Matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) antibody;Matrix Metalloproteinase 9 antibody;MMP 9 antibody;MMP-9 antibody;MMP9 antibody;MMP9_HUMAN antibody;Type V collagenase antibody

SUBCELLULAR LOCATION

Secreted, extracellular space, extracellular matrix.

FUNCTION

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, angiogenesis, bone development, wound healing, cell migration, learning and memory, as well as in pathological processes, such as asthma, arthritis, intracerebral hemorrhage, and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens and other extracellular matrix proteins. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. Thrombospondins, intervertebral disc proteins, regulate interaction with matrix metalloproteinases (MMPs) 2 and 9, which are key effectors of ECM remodeling.