MICA + MICB Recombinant Rabbit Monoclonal Antibody [PSH10-88] (HA723255)

UNIPROT #

Q29980

PROTEIN NAME

MICA + MICB

SYNONYMS

HLA class I antigen antibody;FLJ36918 antibody;FLJ60820 antibody;MGC111087 antibody;MGC21250 antibody;MHC class I chain related gene A protein antibody;MHC class I chain related protein A antibody;MHC class I chain related protein A HLA B HLA C antibody;MHC class I polypeptide related sequence A antibody;MHC class I polypeptide-related sequence A antibody;MHC class I related protein antibody;MIC A antibody;MIC-A antibody;micA antibody;MICA_HUMAN antibody;OTTHUMP00000029088 antibody;OTTHUMP00000044528 antibody;OTTHUMP00000165170 antibody;OTTHUMP00000165172 antibody;PERB11.1 antibody;Stress inducible class I homolog antibody;MHC class I chain related protein B antibody;MHC class I chain related protein B2 antibody;MHC class I like molecule PERB11.2 IMX antibody;MHC class I mic B antigen antibody;MHC class I polypeptide related sequence B antibody;MHC class I polypeptide-related sequence B antibody;MIC B antibody;MIC-B antibody;MICB antibody;MICB_HUMAN antibody;PERB11.2 antibody;Stress inducible class I homolog antibody

SUBCELLULAR LOCATION

Cell membrane, Cytoplasm; Cell membrane.

FUNCTION

MHC class I polypeptide–related sequence A (MICA) is a highly polymorphic cell surface glycoprotein encoded by the MICA gene located within MHC locus. MICA is related to MHC class I and it has similar domain structure, however, it is not associated with β2-microglobulin nor binds peptides as conventional MHC class I molecules do. MICA rather functions as a stress-induced ligand (as a danger signal) for integral membrane protein receptor NKG2D ("natural-killer group 2, member D"). MICA is broadly recognized by NK cells, γδ T cells, and CD8+ αβ T cells which carry NKG2D receptor on their cell surface and which are activated via this interaction. MHC class I polypeptide-related sequence B (MICB) is a protein that is encoded by the MICB gene located within MHC locus. MICB is related to MHC class I and has similar domain structure, which is made up of external α1α2α3 domain, transmembrane segment and C-terminal cytoplasmic tail. MICB is a stress-induced ligand for NKG2D receptor. The heat shock stress pathway is involved in the regulation of MICB expression as transcription of MICB is regulated by promoter heat shock element.