MEK4 / MKK4 Recombinant Rabbit Monoclonal Antibody - BSA and Azide free [PSH11-99] (HA751432)

UNIPROT #

P45985

PROTEIN NAME

MEK4 / MKK4

SYNONYMS

c Jun N terminal kinase kinase 1 antibody;C-JUN N-terminal kinase kinase 1 antibody;Dual specificity mitogen activated protein kinase kinase 4 antibody;Dual specificity mitogen-activated protein kinase kinase 4 antibody;JNK Activated Kinase 1 antibody;JNK activating kinase 1 antibody;JNK-activating kinase 1 antibody;JNKK antibody;JNKK1 antibody;MAP kinase kinase 4 antibody;Map2k4 antibody;MAPK ERK kinase 4 antibody;MAPK/ERK kinase 4 antibody;MAPKK 4 antibody;MAPKK4 antibody;MEK 4 antibody;MEK4 antibody;Mitogen activated protein kinase kinase 4 antibody;MKK 4 antibody;MKK4 antibody;MP2K4_HUMAN antibody;PRKMK4 antibody;SAPK ERK kinase 1 antibody;SAPK/ERK kinase 1 antibody;SAPKK 1 antibody;SAPKK1 antibody;SEK1 antibody;SERK1 antibody;SKK1 antibody;Stress activated protein kinase kinase 1 antibody

SUBCELLULAR LOCATION

Cytoplasm, Nucleus.

FUNCTION

Dual-specificity mitogen-activated protein kinase kinase 4 is an enzyme that in humans is encoded by the MAP2K4 gene. MAP2K4 encodes a dual-specificity kinase that belongs to the Ser/Thr protein kinase family. MAP2K4 phosphorylates MAP kinases in response to various environmental stresses or mitogenic stimuli. MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38 are substrates for MAP2K4, but MAPK1/ERK2 and MAPK3/ERK1 are not phosphorylated by MAP2K4. Structurally, MAP2K4 contains a kinase domain that is phosphorylated and activated by MAP3K1(aka MEKK1). MAP2K4 contains multiple amino acid sites that are phosphorylated and ubiquitinated. Genetic studies using Map2k4 knockout mice revealed embryonic lethality, impaired hepatogenesis and defective liver formation. Analysis of chimeric mice identified a role for Map2k4 in T cell cytokine production and proliferation. Map2k4-deficient chimeric mice frequently develop lymphadenopathy. MAP2K4 is altered in 1.97% of all human cancers.