MCP-3/CCL7 Recombinant Rabbit Monoclonal Antibody [PSH23-04] (HA724344)

UNIPROT #

P80098

PROTEIN NAME

MCP-3/CCL7

SYNONYMS

C-C motif chemokine 7 antibody;Ccl7 antibody;CCL7_HUMAN antibody;Chemokine CC motif ligand 7 antibody;FIC antibody;MARC antibody;MCP-3 antibody;Monocyte chemoattractant protein 3 antibody;Monocyte chemotactic protein 3 antibody;NC28 antibody;RP23-350G1.4 antibody;SCYA6 antibody;SCYA7 antibody;Small-inducible cytokine A7 antibody

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Chemokine (C-C motif) ligand 7 (CCL7) is a small cytokine that was previously called monocyte-chemotactic protein 3 (MCP3). CCL7 is a small protein that belongs to the CC chemokine family and is most closely related to CCL2 (previously called MCP1). CCL7 is expressed in many types of cells, including stromal cells, keratinocytes, airway smooth muscle cells, parenchymal cells, fibroblasts and leukocytes and also in tumor cells. CCL7 mainly acts as a chemoattractant for several leukocytes, including monocytes, eosinophils, basophils, dendritic cells (DCs), neutrophils, NK cells and activated T lymphocytes. Thus, chemotactic factor CCL7 recruits leukocytes to infected tissues to mediate the immune response. Furthermore, CCL7 has an influence to diapedesis and extravasation of leukocytes. The positive effect of CCL7 is mainly observed in monocyte mobilization from bone marrow to blood circulation and in the recruitment of monocytes to sites of inflammation. It was also reported, that CCL7 can also induce neutrophil migration to the inflammatory site by increasing intracellular Ca2+ flux, which is more typical for the CXC chemokine family members. The speed of immune responses varies depending on the type of the cells. In epithelial cells, fibroblasts, and endothelial cells the response is immediate after the stimulation by proinflammatory cytokines as IL-1β and TNFα. In T lymphocytes the expression of CCL7 occurs after 3–5 days after the stimulation. CCL7 has been shown to interact with MMP2 by binding CCR2 receptor.