Mast Cell Tryptase Recombinant Rabbit Monoclonal Antibody (IRS041)

UNIPROT #

Q15661

PROTEIN NAME

Mast Cell Tryptase

SYNONYMS

alpha II antibody;Lung tryptase antibody;Mast cell alpha II tryptase antibody;Mast cell beta I tryptase antibody;Mast cell protease 7 antibody;Mast cell protease II antibody;MCP 7 antibody;Pituitary tryptase antibody;Skin tryptase antibody;TPS 1 antibody;TPS1 antibody;TPS2 antibody;TPSAB1 antibody;TPSAB1 protein antibody;TPSB1 antibody;Tryptase 1 antibody;Tryptase alpha 1 antibody;tryptase alpha I included antibody;Tryptase alpha II antibody;tryptase alpha II included antibody;tryptase alpha included antibody;tryptase alpha/beta 1 antibody;Tryptase beta 1 antibody;tryptase beta I included antibody;Tryptase I antibody;tryptase I included antibody;Tryptase III antibody;Tryptase skin antibody

SEQUENCE SIMILARITIES

Belongs to the peptidase S1 family. Tryptase subfamily.

TISSUE SPECIFICITY

Isoform 1 and isoform 2 are expressed in lung, stomach, spleen, heart and skin; in these tissues, isoform 1 is predominant. Isoform 2 is expressed in aorta, spleen, and breast tumor, with highest levels in the endothelial cells of some blood vessels surrounding the aorta, as well as those surrounding the tumor and low levels, if any, in mast cells (at protein level).

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Mast cells are connective tissue cells derived from blood-forming tissues that line arterial walls and secrete substances, which mediate inflammatory and immune responses. Mast cell chymase, known as CMA1, is a major secreted serine protease that is involved in vasoactive peptide generation, extracellular matrix degradation and regulation of gland secretion. The human chymase gene, which maps to human chromosome 14q11.2, encodes a preproenzyme with a 19-amino acid signal peptide, an acidic 2-amino acid propeptide and a 226-amino acid catalytic domain. Tryptases comprise a family of trypsin-like serine proteases that are enzymatically active as heparin-stabilized tetramers. There are four functional genes for tryptase: α I, β I, β II and γ I, which map to human chromosome 16p13.3, with β tryptases representing the main isoenzymes expressed in mast cells. Mast cell proteases are a family of rodent protein homologs to human tryptases that are specifically expressed in mast cells and may serve as highly specific markers in the analysis of mast cell heterogeneity, differentiation and function.