M6PR (cation dependent) Recombinant Rabbit Monoclonal Antibody - BSA and Azide free [PSH01-06] (HA750681)

UNIPROT #

P20645

PROTEIN NAME

M6PR (cation dependent)

SYNONYMS

46 kDa mannose 6 phosphate receptor antibody;46 kDa mannose 6-phosphate receptor antibody;Cation dependent mannose 6 phosphate receptor antibody;Cation dependent mannose 6 phosphate receptor precursor antibody;Cation-dependent mannose-6-phosphate receptor antibody;CD Man 6 P receptor antibody;CD Man-6-P receptor antibody;CD MPR antibody;CD-M6PR antibody;CD-MPR antibody;FLJ32994 antibody;M6pr antibody;M6PR protein antibody;Man6PR antibody;Mannose 6 phosphate receptor (cation dependent) antibody;Mannose 6 phosphate receptor antibody;MPR 46 antibody;MPR46 antibody;MPRD antibody;MPRD_HUMAN antibody;Mr 46,000 Man6PR antibody;Small mannose 6 phosphate receptor antibody;SMPR antibody

SUBCELLULAR LOCATION

Lysosome membrane.

FUNCTION

In the fields of biochemistry and cell biology, the cation-dependent mannose-6-phosphate receptor (CD-MPR) also known as the 46 kDa mannose 6-phosphate receptor is a protein that in humans is encoded by the M6PR gene. The CD-MPR is one of two transmembrane proteins that bind mannose-6-phosphate (M6P) tags on acid hydrolase precursors in the Golgi apparatus that are destined for transport to the lysosome. Homologues of CD-MPR are found in all eukaryotes. Both CD-MPRs and CI-MPRs are lectins that bind their M6P-tagged cargo in the lumen of the Golgi apparatus. The CD-MPR shows greatly enhanced binding to M6P in the presence of divalent cations, such as manganese. The MPRs (bound to their cargo) are recognized by the GGA family of clathrin adaptor proteins and accumulate in forming clathrin-coated vesicles. They are trafficked to the early endosome where, in the relatively low pH environment of the endosome, the MPRs release their cargo. The MPRs are recycled back to the Golgi, again by way of interaction with GGAs and vesicles. The cargo proteins are then trafficked to the lysosome via the late endosome independently of the MPRs.