LYVE1 Recombinant Rabbit Monoclonal Antibody [PSH23-01] (HA724340)

UNIPROT #

Q8BHC0

PROTEIN NAME

LYVE1

SYNONYMS

Cell surface retention sequence-binding protein 1 antibody;CRSBP 1 antibody;CRSBP-1 antibody;CRSBP1 antibody;extracellular link domain containing 1 antibody;extracellular link domain-containing 1 antibody;Extracellular link domain-containing protein 1 antibody;HAR antibody;Hyaluronic acid receptor antibody;Lymphatic endothelium specific hyaluronan receptor antibody;lymphatic vessel endothelial hyaluronan receptor 1 antibody;Lymphatic vessel endothelial hyaluronic acid receptor 1 antibody;LYVE 1 antibody;LYVE-1 antibody;LYVE1 antibody;XLKD1 antibody

SUBCELLULAR LOCATION

Membrane.

FUNCTION

Lymphatic vessel endothelial hyaluronan receptor 1 (LYVE1), also known as extracellular link domain containing 1 (XLKD1) is a Link domain-containing hyaladherin, a protein capable of binding to hyaluronic acid (HA), homologous to CD44, the main HA receptor. In humans it is encoded by the LYVE1 gene. LYVE1 is a type I integral membrane glycoprotein. It acts as a receptor and binds to both soluble and immobilized hyaluronan. This protein may function in lymphatic hyaluronan transport and have a role in tumor metastasis. LYVE-1 is a cell surface receptor on lymphatic endothelial cells that can be used as a lymphatic endothelial cell marker, allowing for the isolation of these cells for experimental purposes. The physiological role for this receptor is still the subject of debate, but evolutionary conservation suggests an important role. Expression of LYVE1 not restricted to lymph vessels but is also observed in normal liver blood sinusoids, and embryonic blood vessels.