LIS1 Recombinant Rabbit Monoclonal Antibody [JE37-43] (HA722143)

UNIPROT #

P43034

PROTEIN NAME

LIS1

SYNONYMS

LIS 1 antibody;LIS 2 antibody;LIS-1 antibody;LIS1 antibody;LIS1_HUMAN antibody;LIS2 antibody;Lissencephaly 1 protein antibody;Lissencephaly-1 protein antibody;MDCR antibody;MDS antibody;PAF acetylhydrolase 45 kDa subunit antibody;PAF AH 45 kDa subunit antibody;PAF AH alpha antibody;PAF-AH 45 kDa subunit antibody;PAF-AH alpha antibody;PAFAH alpha antibody;PAFAH antibody;PAFAH1B1 antibody;PAFAHA antibody;Platelet activating factor acetylhydrolase 1b regulatory subunit 1 antibody;Platelet activating factor acetylhydrolase isoform Ib alpha subunit antibody;Platelet-activating factor acetylhydrolase IB subunit alpha antibody

SUBCELLULAR LOCATION

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, spindle, Nucleus membrane.

FUNCTION

Platelet-activating factor acetylhydrolase IB subunit alpha is an enzyme that in humans is encoded by the PAFAH1B1 gene. The protein is often referred to as Lis1 and plays an important role in regulating the motor protein Dynein. PAFAH1B1 was identified as encoding a gene that when mutated or lost caused the lissencephaly associated with Miller–Dieker syndrome. PAFAH1B1 encodes the non-catalytic alpha subunit of the intracellular Ib isoform of platelet-activating factor acetylhydrolase, a heterotrimeric enzyme that specifically catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist: one composed of multiple subunits, the other, a single subunit. In addition, a single-subunit isoform of this enzyme is found in serum.