LAT Recombinant Rabbit Monoclonal Antibody [PSH09-76] (HA723141)

UNIPROT #

O43561

PROTEIN NAME

LAT

SYNONYMS

36 kDa phospho tyrosine adapter protein antibody;36 kDa phospho-tyrosine adapter protein antibody;36 kDa phospho-tyrosine adaptor protein antibody;LAT 1 antibody;lat antibody;LAT_HUMAN antibody;LAT1 antibody;Linker for activation of T cells antibody;Linker for activation of T cells family member 1 antibody;linker for activation of T cells, transmembrane adaptor antibody;Linker for activation of T-cells family member 1 antibody;p36 38 antibody;p36-38 antibody;pp36 antibody

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

The Linker for activation of T cells, also known as linker of activated T cells or LAT, is a protein involved in the T-cell antigen receptor signal transduction pathway which in humans is encoded by the LAT gene. Alternative splicing results in multiple transcript variants encoding different isoforms. The LAT protein encoded by the gene of the same name, plays a key role in the diversification of T cell signaling pathways following activation of the T-cell antigen receptor (TCR) signal transduction pathway, which is first catalyzed by TCR binding to MHC class II. LAT is a transmembrane protein localizes to lipid rafts (also known as glycosphingolipid-enriched microdomains or GEMs) and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. In mouse thymocytes, lack of functional LAT or the inability for LAT to be phosphorylated leads to complete lack of T cell development. Moreover, mutation and deletion of LAT hampers overall TCR mediated T cell response.