KMT3B Recombinant Rabbit Monoclonal Antibody - BSA and Azide free [1B1] (HA750507)

UNIPROT #

Q96L73

PROTEIN NAME

KMT3B

SYNONYMS

Androgen receptor coactivator 267 kDa protein antibody;Androgen receptor-associated protein of 267 kDa antibody;ARA267 antibody;H3 K36 HMTase antibody;H3-K36-HMTase antibody;H4 K20 HMTase antibody;H4-K20-HMTase antibody;Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific antibody;KMT3B antibody;Lysine N-methyltransferase 3B antibody;NR binding SET domain containing protein antibody;NR-binding SET domain-containing protein antibody;Nsd1 antibody;NSD1_HUMAN antibody;Nuclear receptor binding SET domain containing protein 1 antibody;Nuclear receptor binding SET domain protein 1 antibody;Nuclear receptor-binding SET domain-containing protein 1 antibody

SUBCELLULAR LOCATION

Nucleus, Chromosome.

FUNCTION

This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11. Multiple transcript variants encoding distinct isoforms have been identified for this gene.