KLKB1 Recombinant Rabbit Monoclonal Antibody [JE31-29] (HA721397)

UNIPROT #

P03952

PROTEIN NAME

KLKB1

SYNONYMS

Fletcher factor antibody;kallikrein B plasma antibody;Kallikrein B plasma (Fletcher factor) 1 antibody;Kallikrein B, plasma 1 antibody;Kallikrein B1 antibody;Kininogenin antibody;KLK3 antibody;KLKB1 antibody;KLKB1_HUMAN antibody;PKK antibody;PKKD antibody;Plasma kallikrein antibody;Plasma kallikrein B1 antibody;Plasma kallikrein light chain antibody;Plasma prekallikrein antibody;PPK antibody;Prekallikrein antibody

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulfide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients. Kallikrein and prekallikrein have been shown to interact with High-molecular-weight kininogen.