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ITPR3 Rabbit Polyclonal Antibody (HA500640)

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Catalog# HA500640

Rabbit Polyclonal to ITPR3

Tested for

  • WB

Reacts with

  • Human

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Specifications

Product Type

Rabbit polyclonal primary

Product Name

ITPR3 Rabbit Polyclonal Antibody (HA500640)

Immunogen

Recombinant protein within human itpr3 850-3,000.

Host

Rabbit

Positive Control

HeLa (Human cervical adenocarcinoma cell) cell lysate, LO2 (Human fetal hepatocyte line) cell lysate, Hep G2 (Human liver cancer cell) cell lysate.

Conjugation

Unconjugated

Clonality

Polyclonal

APPLICATION DILUTION

  • WB

  • 1:10,000

PROPERTIES

Form

Liquid

Storage Condition

Shipped at 4C. Store at +4C short term (1-2 weeks). Store at -20C long term.

Storage Buffer

1*PBS (pH7.4), 0.1% BSA, 40% Glycerol, 0.2% Proclean 950.

Concentration

0.2ug/ul

Purification

Immunogen affinity purified.

Molecular Weight

Predicted band size: 304 kDa

Isotype

IgG

TARGET

UNIPROT #

Q14573

PROTEIN NAME

ITPR3

SYNONYMS

Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3;IP3 receptor isoform 3 (IP3R-3; InsP3R3);Type 3 inositol 1,4,5-trisphosphate receptor (Type 3 InsP3 receptor);ITPR3

SUBCELLULAR LOCATION

Endoplasmic reticulum membrane, Cytoplasmic vesicle, secretory vesicle membrane.

FUNCTION

Inositol 1,4,5-trisphosphate receptor, type 3, also known as ITPR3, is a protein which in humans is encoded by the ITPR3 gene. The protein encoded by this gene is both a receptor for inositol triphosphate and a calcium channel. ITP3 channels serve an important role in the taste transduction pathway of sweet, bitter and umami tastes the gustatory system. ITP3 channels allow the flow of Calcium out of the endoplasmic reticulum in response to IP3. Calcium cations result in the activation of TRPM5 which leads to a depolarisation generating potential and an action potential.

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