ITCH / AIP4 Recombinant Rabbit Monoclonal Antibody [JE31-09] (HA722530)

UNIPROT #

Q96J02

PROTEIN NAME

ITCH / AIP4

SYNONYMS

ADMFD antibody;AIF4 antibody;AIP4 antibody;Atrophin 1 interacting protein 4 antibody;Atrophin-1-interacting protein 4 antibody;dJ468O1.1 antibody;dJ468O1.1 (atrophin 1 interacting protein 4 (AIP4)) antibody;dJ468O1.1 atrophin 1 interacting protein 4 AIP4 antibody;E3 ubiquitin protein ligase Itchy homolog antibody;E3 ubiquitin-protein ligase Itchy homolog antibody;EC 6.3.2 antibody;Itch antibody;ITCH_HUMAN antibody;Itchy E3 ubiquitin protein ligase antibody;Itchy E3 ubiquitin protein ligase homolog antibody;Itchy E3 ubiquitin protein ligase homolog mouse antibody;Itchy E3 ubiquitin protein ligase, mouse, homolog of antibody;Itchy homolog E3 ubiquitin protein ligase antibody;Itchy mouse homolog E3 ubiquitin protein ligase antibody;NAPP1 antibody;NFE2 associated polypeptide 1 antibody;NFE2-associated polypeptide 1 antibody;Ubiquitin protein ligase ITCH antibody

SUBCELLULAR LOCATION

Cell membrane, Cytoplasm, Nucleus, Early endosome membrane, Endosome membrane.

FUNCTION

ITCH is a HECT domain–containing E3 ubiquitin ligase that is ablated in non-agouti-lethal 18H (aka Itchy) mice. Itchy mice develop a severe immunological phenotype after birth that includes hyperplasia of lymphoid and hematopoietic cells, and stomach and lung inflammation. In humans ITCH deficiency causes altered physical growth, craniofacial morphology defects, defective muscle development, and aberrant immune system function. The ITCH gene is located on chromosome 20 in humans. ITCH contains a C2 domain, proline-rich region, WW domains, HECT domain, and multiple amino acids that are phosphorylated and ubiquitinated.