IRF8 Recombinant Rabbit Monoclonal Antibody - BSA and Azide free [PSH10-05] (HA751335)

UNIPROT #

Q02556

PROTEIN NAME

IRF8

SYNONYMS

H ICSBP antibody;H-ICSBP antibody;HGNC:5358 antibody;HICSBP antibody;ICSBP 1 antibody;ICSBP antibody;ICSBP1 antibody;Interferon consensus sequence binding protein 1 antibody;Interferon consensus sequence binding protein antibody;Interferon consensus sequence-binding protein antibody;Interferon regulatory factor 8 antibody;IRF 8 antibody;IRF-8 antibody;Irf8 antibody;IRF8_HUMAN antibody;MYLS antibody

SUBCELLULAR LOCATION

Nucleus, Cytoplasm.

FUNCTION

Interferon regulatory factor 8 (IRF8) also known as interferon consensus sequence-binding protein (ICSBP), is a protein that in humans is encoded by the IRF8 gene. IRF8 is a transcription factor that plays critical roles in the regulation of lineage commitment and in myeloid cell maturation including the decision for a common myeloid progenitor (CMP) to differentiate into a monocyte precursor cell. Interferon Consensus Sequence-binding protein (ICSBP) is a transcription factor of the interferon regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-α and IFN-β. IRF family proteins also control expression of IFN-α and IFN-β-regulated genes that are induced by viral infection.