IL-18 Recombinant Rabbit Monoclonal Antibody [PSH18-15] (HA723978)

UNIPROT #

Q14116

PROTEIN NAME

IL-18

SYNONYMS

Iboctadekin antibody;IFN gamma inducing factor antibody;IFN-gamma-inducing factor antibody;IGIF antibody;IL 1 gamma antibody;IL 18 antibody;IL 1g antibody;IL-1 gamma antibody;IL-18 antibody;IL1 gamma antibody;IL18 antibody;IL18 protein antibody;IL18_HUMAN antibody;IL1F4 antibody;IL1g antibody;IL1gamma antibody;ILIF4 antibody;Interferon gamma inducing factor antibody;Interferon gamma-inducing factor antibody;Interleukin 1 gamma antibody;Interleukin 18 (interferon-gamma-inducing factor) antibody;Interleukin 18 antibody;Interleukin-1 gamma antibody;Interleukin-18 antibody;Interleukin18 antibody;MGC12320 antibody

SUBCELLULAR LOCATION

Cytoplasm, cytosol, Secreted.

FUNCTION

Interleukin-18 (IL-18), also known as interferon-gamma inducing factor is a protein which in humans is encoded by the IL18 gene. The protein encoded by this gene is a proinflammatory cytokine. Many cell types, both hematopoietic cells and non-hematopoietic cells, have the potential to produce IL-18. It was first described in 1989 as a factor that induced interferon-γ (IFN-γ) production in mouse spleen cells. Originally, IL-18 production was recognized in Kupffer cells, liver-resident macrophages. However, IL-18 is constitutively expressed in non-hematopoietic cells, such as intestinal epithelial cells, keratinocytes, and endothelial cells. IL-18 can modulate both innate and adaptive immunity and its dysregulation can cause autoimmune or inflammatory diseases. IL-18 belongs to the IL-1 superfamily and is produced mainly by macrophages but also other cell types, stimulates various cell types and has pleiotropic functions. IL-18 is a proinflammatory cytokine that facilitates type 1 responses. Together with IL-12, it induces cell-mediated immunity following infection with microbial products like lipopolysaccharide (LPS). IL-18 in combination with IL12 acts on CD4, CD8 T cells and NK cells to induce IFNγ production, type II interferon that plays an important role in activating the macrophages or other cells. The combination of this IL-18 and IL-12 has been shown to inhibit IL-4 dependent IgE and IgG1 production and enhance IgG2a production in B cells. Importantly, without IL-12 or IL-15, IL-18 does not induce IFNγ production, but plays an important role in the differentiation of naive T cells into Th2 cells and stimulates mast cells and basophils to produce IL-4, IL-13, and chemical mediators such as histamine.