iFluor™ 594 Conjugated Human CD45 Recombinant Mouse Monoclonal Antibody [PSH03-64] (HA601608F)

UNIPROT #

P08575

PROTEIN NAME

Human CD45

SYNONYMS

B220 antibody;CD 45 antibody;CD45 antibody;CD45 antigen antibody;CD45R antibody;GP180 antibody;L-CA antibody;LCA antibody;Leukocyte common antigen antibody;loc antibody;Ly-5 antibody;LY5 antibody;Ly5, homolog of antibody;Lyt-4 antibody;OTTHUMP00000033813 antibody;OTTHUMP00000033816 antibody;OTTHUMP00000033817 antibody;OTTHUMP00000038574 antibody;Protein tyrosine phosphatase receptor type c polypeptide antibody;Protein tyrosine phosphatase, receptor type C antibody;protein tyrosine phosphatase, receptor type, C antibody;Protein tyrosine phosphatase, receptor type, c polypeptide antibody;Ptprc antibody;PTPRC_HUMAN antibody;Receptor-type tyrosine-protein phosphatase C antibody;T200 antibody;T200 glycoprotein antibody;T200 leukocyte common antigen antibody

SUBCELLULAR LOCATION

Cell membrane, Membrane raft.

FUNCTION

The protein product of this gene, best known as CD45, is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. CD45 contains an extracellular domain, a single transmembrane segment, and two tandem intracytoplasmic catalytic domains, and thus belongs to the receptor type PTP family. CD45 is a type I transmembrane protein that is present in various isoforms on all differentiated hematopoietic cells (except erythrocytes and plasma cells). CD45 has been shown to be an essential regulator of T- and B-cell antigen receptor signalling. It functions through either direct interaction with components of the antigen receptor complexes via its extracellular domain (a form of co-stimulation), or by activating various Src family kinases required for the antigen receptor signaling via its cytoplasmic domain. CD45 also suppresses JAK kinases, and so functions as a negative regulator of cytokine receptor signaling. Many alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. Antibodies against the different isoforms of CD45 are used in routine immunohistochemistry to differentiate between immune cell types, as well as to differentiate between histological sections from lymphomas and carcinomas.