IDO Recombinant Antibody [PD00-62] - Mouse IgG1 (Chimeric) - BSA and Azide free (HA610430)

UNIPROT #

P14902

PROTEIN NAME

IDO

SYNONYMS

3-dioxygenase antibody;I23O1_HUMAN antibody;IDO 1 antibody;IDO antibody;IDO-1 antibody;IDO1 antibody;INDO antibody;indolamine 2,3 dioxygenase antibody;Indole 2 3 dioxygenase antibody;indoleamine 2 3 dioxygenase 1 antibody;indoleamine 2 3 dioxygenase antibody;Indoleamine 2,3-dioxygenase 1 antibody;Indoleamine pyrrole 2 3 dioxygenase antibody;Indoleamine-pyrrole 2 antibody

SUBCELLULAR LOCATION

Cytoplasm, cytosol.

FUNCTION

Indoleamine 2,3-dioxygenase (IDO) is an IFN-γ inducible enzyme that catalyzes the degradation of the essential amino acid L-tryptophan to N-formylkynurenine. The gene encoding human IDO maps to chromosome 8p12-p11. IDO, also known as INDO, is an important modulator of immunological responses and protects allogeneic concepti from alloreactive maternal lymphocytes. IDO mediates an interesting inhibitory effect of HeLa cells co-cultured with human PBLs. The ILN-2-induced proliferation response of PBLs is diminished in the presence of HeLa cells while an IDO inhbitor negates this effect. Flow cytometric analysis indicates both mature and immature CD123-positive dentritic cells suppress T cell activity using IDO. IDO-transfected cells co-cultured with T cells reduces T cell proliferation. Additionally, adopted transfer of donor T cells reduces donor T cell numbers in IDO-transgenic mice. The pharmacological or genetic manipulation of IDO may be useful for supressing undesirable T cell response.