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Iba1 Recombinant Antibody [JM36-62] - Chicken IgY (Chimeric) - BSA and Azide free (HA610221)

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Catalog# HA610221

to Iba1

Tested for

  • IHC-Fr

  • WB

  • IF-Cell

  • FC

Reacts with

  • Human

  • Mouse

  • Rat

  • Pig

  • Cynomolgus monkey

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free

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Specifications

Product Type

Recombinant Chimeric Antibody primary

Product Name

Iba1 Recombinant Antibody [JM36-62] - Chicken IgY (Chimeric) - BSA and Azide free (HA610221)

Immunogen

Synthetic peptide within n-terminal human iba1.

Specificity

This chicken recombinant monoclonal chimeric antibody has been engineered from a himab parent antibody (et1705-78). by necessity, some rabbit sequence is retained as part of the variable domain. when multiplexing with other rabbit-derived antibodies, using cross absorbed fc-reactive secondary antibodies are recommended.

Positive Control

Mouse cerebellum tissue, mouse spleen tissue, THP-1 cell lysate, Mouse spleen tissue lysate, Rat spleen tissue lysate, C6, THP-1.

Conjugation

Unconjugated

Clone Number

JM36-62

APPLICATION DILUTION

  • IHC-Fr

  • 1:500

  • WB

  • 1:5,000

  • IF-Cell

  • 1:100

  • FC

  • 1:1,000

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*PBS (pH7.4).

Concentration

1ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 17 kDa

Isotype

IgY

TARGET

UNIPROT #

P55008

PROTEIN NAME

Iba1

SYNONYMS

AIF 1 antibody;AIF-1 antibody;Aif1 antibody;AIF1 protein antibody;AIF1_HUMAN antibody;Allograft inflammatory factor 1 antibody;Allograft inflammatory factor 1 splice variant G antibody;allograft inflammatory factor-1 splice variant Hara-1 antibody;balloon angioplasty responsive transcription antibody;BART 1 antibody;G1 antibody;G1 putative splice variant of allograft inflamatory factor 1 antibody;IBA 1 antibody;IBA1 antibody;interferon gamma responsive transcript antibody;Interferon responsive transcript 1 antibody;interferon responsive transcript factor 1 antibody;Ionized calcium binding adapter molecule 1 antibody;Ionized calcium-binding adapter molecule 1 antibody;ionized calcium-binding adapter molecule antibody;IRT 1 antibody;IRT1 antibody;Microglia response factor antibody;MRF1 antibody;Protein g1 antibody

SUBCELLULAR LOCATION

Cytoplasm, cytoskeleton, Cell projection, ruffle membrane, Cell projection, phagocytic cup.

FUNCTION

Ionized calcium-binding adapter molecule 1 (Iba1), also known as allograft inflammatory factor-1 (AIF-1), is a 147 amino acid cytoplasmic, calcium-binding protein that is thought to play a role in macrophage activation and function. Iba1, containing two EF domains, is induced by cytokines and interferons. In an unstimulated state, Iba1 colocalizes with actin, and upon stimulation, translocates to lamellipodia. It is also a marker of human microglia and is expressed by macrophages in injured skeletal muscle. The gene encoding Iba1 maps to chromosome 6p21.33 and resides in the tumor necrosis factor (TNF) cluster of genes located in the region represented by the human major histocompatibility complex (MHC).

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