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Human TIM-3/HAVCR2, C-His, Flag Tag (ECD) Protein (HA210850)

Price: Regular price $389.00

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Catalog# HA210850

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  • Human

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Product Details

Product Type

Protein

Product Name

Human TIM-3/HAVCR2, C-His, Flag Tag (ECD) Protein (HA210850)

Predicted molecular mass

22.7 kD

Protein construction description

A DNA sequence encoding the human TIM-3/HAVCR2 protein (Q8TDQ0-1) (Ser 22-Gly 202) was expressed with both His, Flag tag at the C-terminus.

Accession

Q8TDQ0-1

Protein construction

TIM-3/HAVCR2 (22-202) | His | Flag

Source

HEK293

Bio Activity

Testing in progress.

Purity

>95% as determined by SDS-PAGE.

Endotoxin

Less than 1.0 EU per μg by the LAL method.

Formulation

Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.

Species

Human

Background

Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand. Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. In CD8+ cells attenuates TCR-induced signaling, specifically by blocking NF-kappaB and NFAT promoter activities resulting in the loss of IL-2 secretion. The function may implicate its association with LCK proposed to impair phosphorylation of TCR subunits, and/or LGALS9-dependent recruitment of PTPRC to the immunological synapse.

Usage Guide

Shipping

In general, recombinant proteins are provided as lyophilized powder which are shipped with blue ice. Bulk packages of recombinant proteins are provided as frozen liquid which are shipped with dry ice.

Storage

Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20C to -80C It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.

Reconstitution

Reconstitute at 250 μg/ml in sterile water.

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