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Human PRDM1, N-Twin Strep, C-His, Flag Tag Protein (HA210703)

Price: Regular price $379.00

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Catalog# HA210703

Reacts with

  • Human

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Product Details

Product Type

Protein

Product Name

Human PRDM1, N-Twin Strep, C-His, Flag Tag Protein (HA210703)

Predicted molecular mass

28.4 kD

Protein construction description

A DNA sequence encoding the human PRDM1 protein (O75626) (Lys 38-Gln 223) was expressed with a Twin strep tag at the N-terminus and both His, Flag tag at the C-terminus.

Accession

O75626

Protein construction

Twin Strep | PRDM1 (38-223) | His | Flag

Source

E.coli

Bio Activity

Testing in progress.

Purity

>95% as determined by SDS-PAGE.

Endotoxin

Less than 1.0 EU per μg by the LAL method.

Formulation

Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.

Species

Human

Background

Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene.

Usage Guide

Shipping

In general, recombinant proteins are provided as lyophilized powder which are shipped with blue ice. Bulk packages of recombinant proteins are provided as frozen liquid which are shipped with dry ice.

Storage

Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20C to -80C It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.

Reconstitution

Reconstitute at 250 μg/ml in sterile water.

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