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Human OX40 Ligand/TNFSF4, Tag Free Protein (HA211558)

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Catalog# HA211558

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Product Details

Product Type

Protein

Product Name

Human OX40 Ligand/TNFSF4, Tag Free Protein (HA211558)

Predicted molecular mass

15.8 kD

Protein construction description

A DNA sequence encoding the human OX40 Ligand/TNFSF4 protein (P23510-1) (Gln 51-Leu 183) was expressed with tag free.

Accession

P23510-1

Protein construction

OX40 Ligand/TNFSF4 (51-183)

Source

HEK293

Bio Activity

Testing in progress.

Purity

>95% as determined by SDS-PAGE.

Endotoxin

Less than 1.0 EU per μg by the LAL method.

Formulation

Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.

Species

Human

Background

OX40L is the ligand for OX40 (also known as CD134 or TNFRSF4) and is stably expressed on many antigen-presenting cells such as DC2s (a subtype of dendritic cells), macrophages, and activated B lymphocytes. The OX40 molecule, conversely, is present on the surface of activated T lymphocytes (mainly CD4+ T cells), but also on NK cells, NKT cells, and neutrophils. The ligation of OX40-OX40L is a source of survival signal for T cells and enables the development of memory T cells. Signaling through these two molecules also leads to polarization towards Th2 immune response even in an environment with low levels of IL-4 cytokine. OX40L is also present on the surface of many non-immune cells, for example, endothelial cells and smooth muscle cells.

Usage Guide

Shipping

In general, recombinant proteins are provided as lyophilized powder which are shipped with blue ice. Bulk packages of recombinant proteins are provided as frozen liquid which are shipped with dry ice.

Storage

Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20C to -80C It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.

Reconstitution

Reconstitute at 250 μg/ml in sterile water.

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