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Human NKX2-2, N-Twin Strep, C-His, Flag Tag Protein (HA210755)

Price: Regular price $379.00

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Catalog# HA210755

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  • Human

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Product Details

Product Type

Protein

Product Name

Human NKX2-2, N-Twin Strep, C-His, Flag Tag Protein (HA210755)

Predicted molecular mass

17.9 kD

Protein construction description

A DNA sequence encoding the human NKX2-2 protein (O95096) (Asp 20-Lys 128) was expressed with a Twin strep tag at the N-terminus and both His, Flag tag at the C-terminus.

Accession

O95096

Protein construction

Twin Strep | NKX2-2 (20-128) | His | Flag

Source

E.coli

Purity

>90% as determined by SDS-PAGE.

Endotoxin

Less than 1.0 EU per μg by the LAL method.

Formulation

Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.

Species

Human

Background

The protein encoded by this gene contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor. Transcriptional activator involved in the development of insulin-producting beta cells in the endocrine pancreas. May also be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Binds to elements within the NEUROD1 promoter.

Usage Guide

Shipping

In general, recombinant proteins are provided as lyophilized powder which are shipped with blue ice. Bulk packages of recombinant proteins are provided as frozen liquid which are shipped with dry ice.

Storage

Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20C to -80C It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.

Reconstitution

Reconstitute at 250 μg/ml in sterile water

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