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Human LILRB2/CD85d/ILT4, C-His, Flag Tag (ECD) Protein (HA210643)

Price: Regular price $389.00

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Catalog# HA210643

Reacts with

  • Human

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Product Details

Product Type

Protein

Product Name

Human LILRB2/CD85d/ILT4, C-His, Flag Tag (ECD) Protein (HA210643)

Predicted molecular mass

50.4 kD

Protein construction description

A DNA sequence encoding the human LILRB2/CD85d/ILT4 protein (Q8N423) (Gln 22-Val 460) was expressed with both His and Flag tag at the C-terminus.

Accession

Q8N423

Protein construction

LILRB2/CD85d/ILT4 (22-460) | His | Flag

Source

HEK293

Bio Activity

Testing in progress.

Purity

>95% as determined by SDS-PAGE.

Endotoxin

Less than 1.0 EU per μg by the LAL method.

Formulation

Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.

Species

Human

Background

Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles. Involved in the down-regulation of the immune response and the development of tolerance. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M) triggering differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.

Usage Guide

Shipping

In general, recombinant proteins are provided as lyophilized powder which are shipped with blue ice. Bulk packages of recombinant proteins are provided as frozen liquid which are shipped with dry ice.

Storage

Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20C to -80C It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.

Reconstitution

Reconstitute at 250 μg/ml in sterile water.

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