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Human Interferon alpha-2/IFNA2, C-His Tag Protein (HA210644)

Price: Regular price $389.00

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Catalog# HA210644

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  • Human

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Product Details

Product Type

Protein

Product Name

Human Interferon alpha-2/IFNA2, C-His Tag Protein (HA210644)

Predicted molecular mass

20.6 kD

Protein construction description

A DNA sequence encoding the human Interferon alpha-2/IFNA2 protein (P01563) (Cys 24-Glu 188) was expressed with a his tag at the C-terminus.

Accession

P01563

Protein construction

Interferon alpha-2/IFNA2 (24-188) | His

Source

HEK293

Bio Activity

Testing in progress.

Purity

>95% as determined by SDS-PAGE.

Endotoxin

Less than 1.0 EU per μg by the LAL method.

Formulation

Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.

Species

Human

Background

This gene is a member of the alpha interferon gene cluster on chromosome 9. The encoded cytokine is a member of the type I interferon family that is produced in response to viral infection as a key part of the innate immune response with potent antiviral, antiproliferative and immunomodulatory properties. This cytokine, like other type I interferons, binds a plasma membrane receptor made of IFNAR1 and IFNAR2 that is ubiquitously expressed, and thus is able to act on virtually all body cells. The encoded protein is effective in reducing the symptoms and duration of the common cold and in treating many types of cancer, including some hematological malignancies and solid tumors. A deficiency of type I interferon in the blood is thought to be a hallmark of severe COVID-19 and may provide a rationale for a combined therapeutic approach. Produced by macrophages, IFN-alpha have antiviral activities.

Usage Guide

Shipping

In general, recombinant proteins are provided as lyophilized powder which are shipped with blue ice. Bulk packages of recombinant proteins are provided as frozen liquid which are shipped with dry ice.

Storage

Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20C to -80C It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.

Reconstitution

Reconstitute at 250 μg/ml in sterile water.

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