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Human GITR Ligand/TNFSF18, Tag Free Protein (HA211265)

Price: Regular price $1,989.00

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Catalog# HA211265

Reacts with

  • Human

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Product Details

Product Type

Protein

Product Name

Human GITR Ligand/TNFSF18, Tag Free Protein (HA211265)

Predicted molecular mass

15.4 kD

Protein construction description

A DNA sequence encoding the human GITR Ligand/TNFSF18 protein (Q9UNG2) (Leu 49-Ser 177) was expressed with tag free.

Accession

Q9UNG2

Protein construction

GITR Ligand/TNFSF18 (49-177)

Source

HEK293

Bio Activity

Testing in progress.

Purity

>95% as determined by SDS-PAGE.

Endotoxin

Less than 1.0 EU per μg by the LAL method.

Formulation

Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.

Species

Human

Background

Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1. Promotes leukocyte adhesion to endothelial cells. Regulates migration of monocytes from the splenic reservoir to sites of inflammation.

Usage Guide

Shipping

In general, recombinant proteins are provided as lyophilized powder which are shipped with blue ice. Bulk packages of recombinant proteins are provided as frozen liquid which are shipped with dry ice.

Storage

Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20C to -80C It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.

Reconstitution

Reconstitute at 250 μg/ml in sterile water.

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