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Human GFRAL/GFR alpha-like Protein (HA210111)

Price: Regular price $559.00

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Catalog# HA210111

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  • Human

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Product Details

Product Type

Protein

Product Name

Human GFRAL/GFR alpha-like Protein (HA210111)

Predicted molecular mass

The protein has a predicted MW of 40.7 kDa. Due to glycosylation, the protein migrates to 48-62 kDa based on Tris-Bis PAGE result.

Protein construction description

Recombinant Human GFRAL/GFR alpha-like Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus. It contains Ser19-Glu351.

Accession

Q6UXV0

Source

HEK293

Purity

> 95% as determined by Tris-Bis PAGE > 95% as determined by HPLC

Endotoxin

Less than 1EU per μg by the LAL method.

Formulation

Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).Normally 8% trehalose is added as protectant before lyophilization.

Species

Human

Background

GFR alpha -like (GDNF receptor-alpha-like) is a distant member of the GDNFR family of proteins. Mature human GFR alpha-like is a 376 amino acid (aa) type I transmembrane protein. It contains a 333 aa extracellular domain, a 20 aa transmembrane domain and a 23 aa cytoplasmic domain.GFRAL is a brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses.

Usage Guide

Storage

-20 to -80°C for 12 months as supplied from date of receipt. -80°C for 3-6 months after reconstitution. 2-8°C for 2-7 days after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Reconstitution

Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.

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