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Human GADD45B, N-Twin Strep, C-His, Flag Tag Protein (HA210533)

Price: Regular price $379.00

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Catalog# HA210533

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  • Human

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Product Details

Product Type

Protein

Product Name

Human GADD45B, N-Twin Strep, C-His, Flag Tag Protein (HA210533)

Predicted molecular mass

24.5 kD

Protein construction description

A DNA sequence encoding the human GADD45B protein (O75293) (Met 1-Arg 160) was expressed with a Twin strep tag at the N-terminus and both His, Flag tag at the C-terminus.

Accession

O75293

Protein construction

Twin Strep | GADD45B (1-160) | His | Flag

Source

E.coli

Bio Activity

Testing in progress.

Purity

>90% as determined by SDS-PAGE.

Endotoxin

Less than 1.0 EU per μg by the LAL method.

Formulation

Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.

Species

Human

Background

Growth Arrest and DNA Damage-Inducible Protein GADD45 β (GADD45B) is a member of the GADD45 family. GADD45B has been shown to interact with MAP3K4, ASK1, MAP2K7, and GADD45GIP1. GADD45B is involved in the regulation of growth and apoptosis. GADD45B reacts to environmental stresses by mediating activation of stress-responsive MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. In addition, GADD45B participates in the down-regulation of hepatocellular carcinoma (HCC). It may serve as a possible therapeutic target.

Usage Guide

Shipping

In general, recombinant proteins are provided as lyophilized powder which are shipped with blue ice. Bulk packages of recombinant proteins are provided as frozen liquid which are shipped with dry ice.

Storage

Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20C to -80C It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.

Reconstitution

Reconstitute at 250 μg/ml in sterile water.

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