Skip to content

Contact

(857) 353-6600

orders@huabio.com

Human Endostatin/COL18A1, Tag Free Protein (HA211001)

Price: Regular price $379.00

Unit price per 

Product size

Bulk Order Quote   |   Customization Request

Catalog# HA211001

Reacts with

  • Human

Safety datasheet

Select your chosen country/region

COA DOWNLOAD

Product Details

Product Type

Protein

Product Name

Human Endostatin/COL18A1, Tag Free Protein (HA211001)

Predicted molecular mass

20.9 kD

Protein construction description

A DNA sequence encoding the human Endostatin/COL18A1 protein (P39060-3) (His 1572-Lys 1754) was expressed with tag free.

Accession

P39060-3

Protein construction

Endostatin/COL18A1 (1572-1754)

Source

HEK293

Bio Activity

Testing in progress.

Purity

>95% as determined by SDS-PAGE.

Endotoxin

Less than 1.0 EU per μg by the LAL method.

Formulation

Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.

Species

Human

Background

This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. A long isoform of the protein has an N-terminal domain that is homologous to the extracellular part of frizzled receptors. Proteolytic processing at several endogenous cleavage sites in the C-terminal domain results in production of endostatin, a potent antiangiogenic protein that is able to inhibit angiogenesis and tumor growth. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternative splicing results in multiple transcript variants.

Usage Guide

Shipping

In general, recombinant proteins are provided as lyophilized powder which are shipped with blue ice. Bulk packages of recombinant proteins are provided as frozen liquid which are shipped with dry ice.

Storage

Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20C to -80C It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.

Reconstitution

Reconstitute at 250 μg/ml in sterile water.

Close (esc)

Popup

Use this popup to embed a mailing list sign up form. Alternatively use it as a simple call to action with a link to a product or a page.

Age verification

By clicking enter you are verifying that you are old enough to consume alcohol.

Enter

Search

Main menu

Your cart is currently empty.
Shop now