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Human CD83, C-His Tag Protein (HA211203)

Price: Regular price $110.00

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Catalog# HA211203

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  • Human

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Product Details

Product Type

Protein

Product Name

Human CD83, C-His Tag Protein (HA211203)

Predicted molecular mass

15.9 kD

Protein construction description

A DNA sequence encoding the human CD83 protein (Q01151) (Thr 20-Ala 143) was expressed with a His tag at the C-terminus.

Accession

Q01151

Protein construction

CD83 (20-143) | His

Source

HEK293

Bio Activity

Testing in progress.

Purity

>95% as determined by SDS-PAGE.

Endotoxin

Less than 1.0 EU per μg by the LAL method.

Formulation

Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.

Species

Human

Background

CD83 (Cluster of Differentiation 83) is a human protein encoded by the CD83 gene. The membrane-bound form of CD83 consists of an extracellular V-type immunoglobulin-like domain, a transmembrane domain and a cytoplasmic signaling tail. A free soluble form consists of the immunoglobulin-like domain alone. Membrane-bound CD83 is expected to form trimers. Soluble CD83 is able to assemble into dodecameric complexes. The CD83 gene is located on human chromosome 6p23 and mouse chromosome 13. In humans, a promoter 261 bp upstream consists of five NF-κB and three interferon regulatory factor binding sites, reflecting the involvement of CD83 in inflammation, as well as binding sites for the aryl hydrocarbon receptor. The latter also occur in an enhancer sequence located 185 bp downstream, inside the second intron, and may suggest negative regulation of transcription by microbial metabolites produced in the gut.

Usage Guide

Shipping

In general, recombinant proteins are provided as lyophilized powder which are shipped with blue ice. Bulk packages of recombinant proteins are provided as frozen liquid which are shipped with dry ice.

Storage

Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃ It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.

Reconstitution

Reconstitute at 250 μg/ml in sterile water.

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