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Human Ataxin-3/ATXN3, C-His Tag Protein (HA211529)

Price: Regular price $169.00

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Catalog# HA211529

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  • Human

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Product Details

Product Type

Protein

Product Name

Human Ataxin-3/ATXN3, C-His Tag Protein (HA211529)

Predicted molecular mass

43.7 kD

Protein construction description

A DNA sequence encoding the human Ataxin-3/ATXN3 protein (P54252-2) (Met 1-Lys 361) was expressed with a His tag at the C-terminus.

Accession

P54252-2

Protein construction

Ataxin-3/ATXN3 (1-361) | His

Source

E.coli

Bio Activity

Testing in progress.

Purity

>95% as determined by SDS-PAGE.

Endotoxin

Less than 1.0 EU per μg by the LAL method.

Formulation

Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.

Species

Human

Background

Ataxin-3 is a protein that in humans is encoded by the ATXN3 gene. Machado–Joseph disease, also known as spinocerebellar ataxia type 3, is an autosomal dominant neurologic disorder. The protein encoded by the ATXN3 gene contains CAG repeats in the coding region, and the expansion of these repeats from the normal 13-36 to 68-79 is the cause of Machado–Joseph disease. This disorder is thus a trinucleotide repeat disorder type I known as a polyglutamine (PolyQ) disease. There is an inverse correlation between the age of onset and CAG repeat numbers. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Usage Guide

Shipping

In general, recombinant proteins are provided as lyophilized powder which are shipped with blue ice. Bulk packages of recombinant proteins are provided as frozen liquid which are shipped with dry ice.

Storage

Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃ It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.

Reconstitution

Reconstitute at 250 μg/ml in sterile water.

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