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Human ANGPTL3/Angiopoietin-like 3, Tag Free Protein (HA211029)

Price: Regular price $379.00

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Catalog# HA211029

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  • Human

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Product Details

Product Type

Protein

Product Name

Human ANGPTL3/Angiopoietin-like 3, Tag Free Protein (HA211029)

Predicted molecular mass

52.2 kD

Protein construction description

A DNA sequence encoding the human ANGPTL3/Angiopoietin-like 3 protein (Q9Y5C1) (Ser17-Glu 460) was expressed with tag free.

Accession

Q9Y5C1

Protein construction

ANGPTL3/Angiopoietin-like 3 (17-460)

Source

HEK293

Bio Activity

Testing in progress.

Purity

>95% as determined by SDS-PAGE.

Endotoxin

Less than 1.0 EU per μg by the LAL method.

Formulation

Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.

Species

Human

Background

Angiopoietin-like 3, also known as ANGPTL3, is a protein that in humans is encoded by the ANGPTL3 gene. The protein encoded by this gene is a member of the angiopoietin-like family of secreted factors. It is expressed predominantly in the liver, and has the characteristic structure of angiopoietins, consisting of a signal peptide, N-terminal coiled-coil domain, and the C-terminal fibrinogen (FBN)-like domain. The FBN-like domain in angiopoietin-like 3 protein was shown to bind alpha-5/beta-3 integrins, and this binding induced endothelial cell adhesion and migration. This protein may also play a role in the regulation of angiogenesis.

Usage Guide

Shipping

In general, recombinant proteins are provided as lyophilized powder which are shipped with blue ice. Bulk packages of recombinant proteins are provided as frozen liquid which are shipped with dry ice.

Storage

Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20C to -80C It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.

Reconstitution

Reconstitute at 250 μg/ml in sterile water.

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