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Human A2M/alpha-2-macroglobulin, C-His Tag Protein (HA210693)

Price: Regular price $389.00

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Catalog# HA210693

Reacts with

  • Human

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Product Details

Product Type

Protein

Product Name

Human A2M/alpha-2-macroglobulin, C-His Tag Protein (HA210693)

Predicted molecular mass

64.3 kD

Protein construction description

A DNA sequence encoding the human A2M/alpha-2-macroglobulin protein (P01023) (Glu 906-Ala 1474) was expressed with a His tag at the C-terminus.

Accession

P01023

Protein construction

A2M/alpha-2-macroglobulin (906-1474) | His

Source

HEK293

Bio Activity

Testing in progress.

Purity

>95% as determined by SDS-PAGE.

Endotoxin

Less than 1.0 EU per μg by the LAL method.

Formulation

Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.

Species

Human

Background

Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.

Usage Guide

Shipping

In general, recombinant proteins are provided as lyophilized powder which are shipped with blue ice. Bulk packages of recombinant proteins are provided as frozen liquid which are shipped with dry ice.

Storage

Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20C to -80C It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.

Reconstitution

Reconstitute at 250 μg/ml in sterile water.

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