HNF-4-alpha Recombinant Rabbit Monoclonal Antibody - BSA and Azide free [SN72-03] (HA750254)

UNIPROT #

P41235

PROTEIN NAME

HNF-4-alpha

SYNONYMS

FLJ39654 antibody;FRTS4 antibody;Hepatic nuclear factor 4 alpha antibody;Hepatocyte nuclear factor 4 alpha antibody;Hepatocyte nuclear factor 4 antibody;Hepatocyte nuclear factor 4-alpha antibody;HNF 4 alpha antibody;HNF 4 antibody;HNF-4-alpha antibody;HNF4 antibody;HNF4A antibody;HNF4A_HUMAN antibody;HNF4a7 antibody;HNF4a8 antibody;HNF4a9 antibody;Hnf4alpha antibody;HNF4alpha10/11/12 antibody;MODY 1 antibody;MODY antibody;MODY1 antibody;NR2A1 antibody;NR2A21 antibody;Nuclear receptor subfamily 2 group A member 1 antibody;OTTHUMP00000031060 antibody;OTTHUMP00000031062 antibody;TCF 14 antibody;TCF antibody;TCF-14 antibody;TCF14 antibody;Tcf4 antibody;Transcription factor 14, hepatic nuclear factor antibody;Transcription factor 14 antibody;Transcription factor HNF 4 antibody;Transcription factor HNF-4 antibody;Transcription factor HNF4 antibody

SEQUENCE SIMILARITIES

Belongs to the nuclear hormone receptor family. NR2 subfamily.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated on tyrosine residue(s); phosphorylation is important for its DNA-binding activity. Phosphorylation may directly or indirectly play a regulatory role in the subnuclear distribution. Phosphorylation at Ser-313 by AMPK reduces the ability to form homodimers and bind DNA.; Acetylation at Lys-458 lowers transcriptional activation by about two-fold.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

HNF-4 alpha is a transcription factor that binds DNA as a homodimer. HNF-4 alpha is important in liver, kidney, and intestinal development. It has also been intensely studied as one of a variety of genes responsible for diabetes mellitus. HNF-4 alpha has been shown in knock out mice to be essential for the morphogenic and functional differentiation of hepatocytes. HNF-4 alpha is a dominant regulator of epithelial phenotypes able to drive the mesenchymal-to-epithelial transition when expressed in fibroblasts.