HNF-4-alpha Recombinant Rabbit Monoclonal Antibody (IRS055)

UNIPROT #

P49698

PROTEIN NAME

HNF-4-alpha

SYNONYMS

FLJ39654 antibody;FRTS4 antibody;Hepatic nuclear factor 4 alpha antibody;Hepatocyte nuclear factor 4 alpha antibody;Hepatocyte nuclear factor 4 antibody;Hepatocyte nuclear factor 4-alpha antibody;HNF 4 alpha antibody;HNF 4 antibody;HNF-4-alpha antibody;HNF4 antibody;HNF4A antibody;HNF4A_HUMAN antibody;HNF4a7 antibody;HNF4a8 antibody;HNF4a9 antibody;Hnf4alpha antibody;HNF4alpha10/11/12 antibody;MODY 1 antibody;MODY antibody;MODY1 antibody;NR2A1 antibody;NR2A21 antibody;Nuclear receptor subfamily 2 group A member 1 antibody;OTTHUMP00000031060 antibody;OTTHUMP00000031062 antibody;TCF 14 antibody;TCF antibody;TCF-14 antibody;TCF14 antibody;Tcf4 antibody;Transcription factor 14, hepatic nuclear factor antibody;Transcription factor 14 antibody;Transcription factor HNF 4 antibody;Transcription factor HNF-4 antibody;Transcription factor HNF4 antibody

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms.