HNF-1B Rabbit Polyclonal Antibody (HA500622)

UNIPROT #

P35680

PROTEIN NAME

HNF-1B

SYNONYMS

FJHN antibody;Hepatocyte nuclear factor 1 beta antibody;Hepatocyte nuclear factor 1-beta antibody;HNF 1B antibody;HNF 2 antibody;HNF-1-beta antibody;HNF-1B antibody;HNF1 beta antibody;HNF1 homeobox B antibody;HNF1B antibody;HNF1B_HUMAN antibody;HNF1beta antibody;HNF2 antibody;Homeoprotein LF B3 antibody;Homeoprotein LFB3 antibody;HPC11 antibody;LF B3 antibody;LFB3 antibody;MODY 5 antibody;MODY5 antibody;TCF 2 antibody;TCF 2 protein antibody;TCF-2 antibody;TCF2 antibody;TCF2 protein antibody;Transcription factor 2 antibody;Transcription factor 2 hepatic antibody;Variant hepatic nuclear factor 1 antibody;Variant hepatic nuclear factor antibody;VHNF 1 antibody;vHNF1 antibody;HNF-1β;HNF 1β

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

HNF1 homeobox B (hepatocyte nuclear factor 1 homeobox B), also known as HNF1B or transcription factor 2 (TCF2), is a human gene. HNF1B encodes hepatocyte nuclear factor 1-beta, a protein of the homeobox-containing basic helix-turn-helix family. The HNF1B protein is believed to form heterodimers with another member of this transcription factor family, HNF1A; depending on the HNF1B isoform, the result may be to activate or inhibit transcription of target genes. Deficiency of HNF1B cause abnormal maternal-Zygote transition and early embryogenesis failure. Mutation of HNF1B that disrupts normal function has been identified as the cause of MODY 5 (Maturity-Onset of Diabetes, Type 5). A third human transcript variant is believed to exist based on such a variant in the rat: however, to date such an mRNA species has not been isolated.