HLA-ABC (MHC I) Recombinant Rabbit Monoclonal Antibody [PSH12-02] (HA723415)

UNIPROT #

P04439

PROTEIN NAME

HLA-ABC (MHC I)

SYNONYMS

Antigen Presenting Molecule antibody;Cw*1701 antibody;D6S204 antibody;FLJ27082 antibody;HLA A antibody;HLA B antibody;HLA C antibody;HLA class 1 A antibody;HLA class 1 B antibody;HLA class 1 C antibody;HLA JY3 antibody;HLAA antibody;HLAB antibody;HLAC antibody;HLC C antibody;Human Leucocyte Antigen C antibody;Major Histocompatibility Complex Class I A antibody;Major Histocompatibility Complex Class I B antibody;Major Histocompatibility Complex Class I C antibody;Major histocompatibility complex, class I, A + B + C antibody;MHC class I antigen A*1 antibody;MHC Class I Antigen antibody;MHC class I antigen B*7 antibody;MHC class I antigen Cw*1 antibody;MHC class I HLA A antibody;MHC class I HLA B antibody;MHC class I HLA C antibody;MHC HLA ABC antibody;PSORS1 antibody

SUBCELLULAR LOCATION

Cell membrane, Endoplasmic reticulum membrane.

FUNCTION

MHC class I molecules are one of two primary classes of major histocompatibility complex (MHC) molecules (the other being MHC class II) and are found on the cell surface of all nucleated cells in the bodies of vertebrates. They also occur on platelets, but not on red blood cells. Their function is to display peptide fragments of proteins from within the cell to cytotoxic T cells; this will trigger an immediate response from the immune system against a particular non-self antigen displayed with the help of an MHC class I protein. Because MHC class I molecules present peptides derived from cytosolic proteins, the pathway of MHC class I presentation is often called cytosolic or endogenous pathway. In humans, the HLAs corresponding to MHC class I are HLA-A, HLA-B, and HLA-C.