HER3 Recombinant Rabbit Monoclonal Antibody [R5] (HA721126)

UNIPROT #

P21860

PROTEIN NAME

HER3

SYNONYMS

c erbB 3 antibody;c erbB3 antibody;Erb b2 receptor tyrosine kinase 3 antibody;ErbB 3 antibody;ERBB3 antibody;ERBB3 protein antibody;erbB3 S antibody;ERBB3_HUMAN antibody;Glial growth factor receptor antibody;HER 3 antibody;HER3 antibody;Human epidermal growth factor receptor 3 antibody;LCCS2 antibody;MDA BF 1 antibody;MGC88033 antibody;p180 ErbB3 antibody;p45 sErbB3 antibody;p85 sErbB3 antibody;proto-oncogene-like protein c ErbB 3 antibody;proto-oncogene-like protein c ErbB3 antibody;Proto-oncogene-like protein c-ErbB-3 antibody;Receptor tyrosine protein kinase erbB 3 antibody;Receptor tyrosine protein kinase erbB3 antibody;Receptor tyrosine-protein kinase erbB-3 antibody;Tyrosine kinase type cell surface receptor HER3 antibody;Tyrosine kinase-type cell surface receptor HER3 antibody;v erb b2 avian erythroblastic leukemia viral oncogene homolog 3 antibody;v erb b2 erythroblastic leukemia viral oncogene homolog 3 (avian) antibody;v erb b2 erythroblastic leukemia viral oncogene homolog 3 antibody

SUBCELLULAR LOCATION

Cell membrane; Secreted.

FUNCTION

This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.